Current spectrum of causative pathogens in sepsis: A prospective nationwide cohort study in Japan

BackgroundThere is no one-size-fits-all empiric antimicrobial therapy for sepsis because the pathogens vary according to site of infection and have changed over time. Therefore, updating knowledge on spectrum necessary rapid administration appropriate antimicrobials.ObjectiveThe aim this study was elucidate current its variation by in sepsis.MethodsThis a prospective nationwide cohort consecutive adult patients with 59 intensive care units Japan. The evaluated all subgroups infection. Regression analyses were conducted evaluate associations between mortality.ResultsThe comprised 1184 patients. most common pathogen Escherichia coli (21.5%), followed Klebsiella pneumoniae (9.0%). However, pattern varied widely infection; example, gram-positive bacteria dominant bone/soft tissue (55.7%) cardiovascular (52.6%), but rarely identified urinary tract (6.4%). In contrast, gram-negative predominant abdominal (38.4%) (72.0%). highest mortality 47.5% observed infected methicillin-resistant Staphylococcus aureus, which significantly associated an increased risk death (odds ratio 1.88, 95% confidence interval 1.22–2.91).ConclusionsThis revealed based infection, essential against sepsis.